Cascilla is an unincorporated community located in Tallahatchie County, Mississippi. Cascilla is approximately 7 miles southeast of Paynes and approximately 6 miles south of Charleston on Cascilla Road.Although an unincorporated community, Cascilla has a post office and a zip code of 38920.Jamie L. Whitten, the second-longest serving U.S. Representative and the fifth-longest serving member of the U.S. Congress, was born in Cascilla.